The adhesion ability and adaptability of bacteria, coupled with constant use of the same bactericides, have made the increase in\nthe diversity of treatments against infections necessary. Nanotechnology has played an important role in the search for new ways\nto prevent and treat infections, including the use of metallic nanoparticles with antibacterial properties. In this study, we worked\non the design of a composite of silver nanoparticles (AgNPS) embedded in poly-epsilon-caprolactone nanofibers and evaluated\nits antimicrobial properties against various Gram-positive and Gram-negative microorganisms associated with drug-resistant\ninfections. Polycaprolactone-silver composites (PCL-AgNPs) were prepared in two steps.The first step consisted in the reduction\nin situ of Ag+ ions using N,N-dimethylformamide (DMF) in tetrahydrofuran (THF) solution, and the second step involved the\nsimple addition of polycaprolactone before electrospinning process. Antibacterial activity of PCL-AgNPs nanofibers against E. coli,\nS.mutans, K. pneumoniae, S. aureus, P. aeruginosa, and B. subtilis was evaluated. Results showed sensibility of E. coli, K. pneumoniae,\nS. aureus, and P. aeruginosa, but not for B. subtilis and S. mutans. This antimicrobial activity of PCL-AgNPs showed significant\npositive correlations associated with the dose-dependent effect. The antibacterial property of the PCL/Ag nanofibers might have\nhigh potential medical applications in drug-resistant infections.
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